کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4355013 | 1299139 | 2007 | 6 صفحه PDF | دانلود رایگان |
Ejaculation, although mediated by a spinal ejaculation generator, is subject to descending supraspinal modulation from several brain regions. 5-hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C receptors, both spinally and supraspinally. By contrast, stimulation of 5-HT1A receptors precipitates ejaculation. Selective serotonin reuptake inhibitors (SSRIs), which are used for treatment of psychiatric disorders, can delay ejaculation in humans and are widely used ‘off-label’ for treatment of premature ejaculation. SSRIs require 1–2 weeks’ chronic dosing to be effective, similar to their use for treatment of depression. However, a new short-acting SSRI is effective ‘on demand’ and might represent the first of a new generation of therapies targeted to premature ejaculation.
Journal: - Volume 30, Issue 2, February 2007, Pages 79–84