کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4357451 | 1615849 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amphotericin B resistance leads to enhanced proteinase and phospholipase activity and reduced germ tube formation in Candida albicans
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
Resistance to amphotericin B is an emerging phenomenon in Candida albicans. Amphotericin B-resistant strain of C. albicans was developed under laboratory conditions and the stability of acquired resistance was confirmed in vitro as well as in vivo. This AMB-resistant strain exhibited reduced germ tube formation as compared to parent strain of C. albicans (ATCC10231). Enzymatic activity of virulence factors like secreted aspartyl proteinase and phospholipase were found to be significantly high in AMB-R as compared to parent strain whereas ergosterol content of AMB-R was drastically reduced. The behavior of AMB-R strain is an interesting phenomenon and opens up a wide area of research regarding pathways and mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Biology - Volume 114, Issues 2–3, February–March 2010, Pages 189–197
Journal: Fungal Biology - Volume 114, Issues 2–3, February–March 2010, Pages 189–197
نویسندگان
Rohitashw Kumar, P.K. Shukla,