کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
443935 692820 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Automatic carotid artery distensibility measurements from CTA using nonrigid registration
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر گرافیک کامپیوتری و طراحی به کمک کامپیوتر
پیش نمایش صفحه اول مقاله
Automatic carotid artery distensibility measurements from CTA using nonrigid registration
چکیده انگلیسی

The distensibility of a blood vessel is a marker of atherosclerotic disease. In this paper we investigate the feasibility of measuring carotid artery distensibility on 4D CTA, both manually and using a new automatic method. On 4D CTA datasets manual (n = 38) and automatic (n = 76) measurements of the carotid distensibility were performed. A subset (n = 10) of the manual annotations were repeated by a second observer. The interobserver variability was assessed using a Bland–Altman analysis and appeared to be too large to reliably measure the distensibility using manual annotation. We compared two versions of the automatic method: one using 3D registration and one using a 4D registration method. The latter resulted in a more smooth deformation over time. The automatic method was evaluated using a synthetic deformation and by investigating whether known relations with cardiovascular risk factors could be reproduced. The relation between distensibility and cardiovascular risk factors was tested with a Mann–Whitney U test. Automatic measurements revealed an association with hypertension whereas the manual measurements did not. This relation has been found by other studies too. We conclude that carotid artery distensibility measurements should be performed automatically and that the method described in this paper is suitable for that. All CTA datasets and related clinical data used in this study can be downloaded from our website (http://ctadist.bigr.nl).

Figure optionsDownload high-quality image (140 K)Download as PowerPoint slideHighlights
► Carotid distensibility measurements on ECG-gated CTA.
► Assessment of manual and automatic measurements.
► Automatic measurements using 4D registration and levelset based segmentation.
► Association of cardiovascular risk factors and carotid distensibility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Image Analysis - Volume 17, Issue 5, July 2013, Pages 515–524
نویسندگان
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