کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
445210 693154 2011 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple q-shell diffusion propagator imaging
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر گرافیک کامپیوتری و طراحی به کمک کامپیوتر
پیش نمایش صفحه اول مقاله
Multiple q-shell diffusion propagator imaging
چکیده انگلیسی

Many recent high angular resolution diffusion imaging (HARDI) reconstruction techniques have been introduced to infer an orientation distribution function (ODF) of the underlying tissue structure. These methods are more often based on a single-shell (one b-value) acquisition and can only recover angular structure information contained in the ensemble average propagator (EAP) describing the three-dimensional (3D) average diffusion process of water molecules. The EAP can thus provide richer information about complex tissue microstructure properties than the ODF by also considering the radial part of the diffusion signal. In this paper, we present a novel technique for analytical EAP reconstruction from multiple q-shell acquisitions. The solution is based on a Laplace equation by part estimation between the diffusion signal for each shell acquisition. This simplifies greatly the Fourier integral relating diffusion signal and EAP, which leads to an analytical, linear and compact EAP reconstruction. An important part of the paper is dedicated to validate the diffusion signal estimation and EAP reconstruction on real datasets from ex vivo phantoms. We also illustrate multiple q-shell diffusion propagator imaging (mq-DPI) on a real in vivo human brain and perform a qualitative comparison against state-of-the-art diffusion spectrum imaging (DSI) on the same subject. mq-DPI is shown to reconstruct robust EAP from only several different b-value shells and less diffusion measurements than DSI. This opens interesting perspectives for new q-space sampling schemes and tissue microstructure investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Image Analysis - Volume 15, Issue 4, August 2011, Pages 603–621
نویسندگان
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