کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4490030 1317749 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Production of Transgenic Animals Using Spermatogonial Stem Cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Production of Transgenic Animals Using Spermatogonial Stem Cells
چکیده انگلیسی

Spermatogonial stem cells (SSCs) are a type of adult stem cell found in male mammals. These cells have the capacity for self renewal and are capable of differentiating in the niche of testis. They are also the only adult stem cells in a normal postnatal body that undergo self-renewal throughout life, transferring genetic information to the offspring. Since a technique for transplanting SSCs was first described by Brinster and his colleagues in 1994, more and more researchers have become interested in exploring the possibility of utilizing adult SSCs to generate transgenic animals. In this minireview, we attempt to summarize the current research progress in the area of spermatogonial stem cells including the source, types and differentiation of the SSCs, and the application on transgenic animals, with a particular focus on the strategy of SSCs delivery including seminiferous tubule injection and spermatogonial stem cell transplantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Agricultural Sciences in China - Volume 10, Issue 5, May 2011, Pages 762-768