کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496021 1623831 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of quasi-steady state methods to molecular motor transport on microtubules in fungal hyphae
ترجمه فارسی عنوان
استفاده از روش های حالت نیمه ثابت برای انتقال مولکولی در میکروتوبول ها در هیف های قارچی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• We model transport of early endosomes by kinesin and dynein on microtubules (MT).
• Quasi-steady state reduction to a Fokker–Plank equation is solvable in closed form.
• We relate bulk diffusion-advection rates to motor speeds and state transition rates.
• MT polarity and motor competition bias cargo density (towards cell ends or centre).
• Motor mutations (kin-ts, dyn-ts) are linked to changes in motor/cargo distributions.

We consider bidirectional transport of cargo by molecular motors dynein and kinesin that walk along microtubules, and/or diffuse in the cell. The motors compete to transport cargo in opposite directions with respect to microtubule polarity (towards the plus or minus end of the microtubule). In recent work, Gou et al. (2014) used a hierarchical set of models, each consisting of continuum transport equations to track the evolution of motors and their cargo (early endosomes) in the specific case of the fungus Ustilago maydis. We complement their work using a framework of quasi-steady state analysis developed by Newby and Bressloff (2010) and Bressloff and Newby (2013) to reduce the models to an approximating steady state Fokker–Plank equation. This analysis allows us to find analytic approximations to the steady state solutions in many cases where the full models are not easily solved. Consequently, we can make predictions about parameter dependence of the resulting spatial distributions. We also characterize the overall rates of bulk transport and diffusion, and how these are related to state transition parameters, motor speeds, microtubule polarity distribution, and specific assumptions made.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 379, 21 August 2015, Pages 47–58
نویسندگان
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