کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496483 1623889 2013 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mathematical model of the human menstrual cycle for the administration of GnRH analogues
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A mathematical model of the human menstrual cycle for the administration of GnRH analogues
چکیده انگلیسی

The paper presents a differential equation model for the feedback mechanisms between gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), development of follicles and corpus luteum, and the production of estradiol (E2), progesterone (P4), inhibin A (IhA), and inhibin B (IhB) during the female menstrual cycle. Compared to earlier human cycle models, there are three important differences: The model presented here (a) does not involve any delay equations, (b) is based on a deterministic modeling of the GnRH pulse pattern, and (c) contains less differential equations and less parameters. These differences allow for a faster simulation and parameter identification. The focus is on modeling GnRH-receptor binding, in particular, by inclusion of a pharmacokinetic/pharmacodynamic (PK/PD) model for a GnRH agonist, Nafarelin, and a GnRH antagonist, Cetrorelix, into the menstrual cycle model. The final mathematical model describes the hormone profiles (LH, FSH, P4, E2) throughout the menstrual cycle of 12 healthy women. It correctly predicts hormonal changes following single and multiple dose administration of Nafarelin or Cetrorelix at different stages in the cycle.


► Menstrual cycle feedback mechanisms are described using differential equations.
► GnRH, FSH, LH, E2, P4, inhibins A and B, and follicular development are modeled.
► The model predicts hormonal changes following GnRH analogue administration.
► Simulation results agree with measurements of hormone blood concentrations.
► The model gives insight into mechanisms underlying gonadotropin suppression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 321, 21 March 2013, Pages 8–27
نویسندگان
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