کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496579 1623895 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advance of advantageous genes for a multiple-allele population genetics model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Advance of advantageous genes for a multiple-allele population genetics model
چکیده انگلیسی

This paper extends the classical result of Fisher (1937) from the case of two alleles to the case of multiple alleles. Consider a population living in a homogeneous one-dimensional infinite habitat. Individuals in this population carry a gene that occurs in k   forms, called alleles. Under the joint action of migration and selection and some additional conditions, the frequencies of the alleles, pi,i=1,…,kpi,i=1,…,k, satisfy a system of differential equations of the form (1.2). In this paper, we first show that under the conditions A1A1A1A1 is the most fit among the homozygotes, (1.2) is cooperative, the state that only allele A1 is present in the population is stable, and the state that allele A1 is absent and all other alleles are present in the population is unstable, then there exists a positive constant, c⁎, such that allele A1 propagates asymptotically with speed c⁎ in the population as t→∞t→∞. We then show that traveling wave solutions connecting these two states exist for |c|≥c⁎|c|≥c⁎. Finally, we show that under certain additional conditions, there exists an explicit formula for c⁎. These results allow us to estimate how fast an advantageous gene propagates in a population under selection and migration forces as t→∞t→∞. Selection is one of the major evolutionary forces and understanding how it works will help predict the genetic makeup of a population in the long run.


► We extend the classical result of Fisher from two alleles to multiple alleles.
► We show that the advantageous allele has a positive propagation speed c⁎.
► We show that traveling wave solutions with speed c   exist for |c|≥c⁎|c|≥c⁎.
► Under certain conditions, we show that c⁎ has an explicit formula.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 315, 21 December 2012, Pages 1–8
نویسندگان
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