کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4496730 | 1623909 | 2012 | 5 صفحه PDF | دانلود رایگان |
It has been shown that density functions of organ transit time distributions of vascular markers (washout curves) are characterized by a power-law tail, reflecting the fractal nature of the vascular network. Yet, thus far, no closed-form model is available that can be fitted to such organ outflow data. Here we propose a model that accounts for the existing data. The model is a continuous mixture of inverse Gaussian densities, implying flow heterogeneity in the organ. It has been fitted to outflow data from the rabbit heart and rat liver. The power-law decay with exponent -3 observed in the heart, corresponds to an intra-organ flow distribution with a relative dispersion of about 35%.
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► Closed-form model for intravascular tracer washout that also describes the power-law tail.
► Rabbit heart and rat liver data.
► Intra-organ flow distribution determines power-law decay exponent.
Journal: Journal of Theoretical Biology - Volume 301, 21 May 2012, Pages 57–61