کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496767 1623910 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A computational model of the topographic distribution of ventilation in healthy human lungs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A computational model of the topographic distribution of ventilation in healthy human lungs
چکیده انگلیسی

The topographic distribution of ventilation in the lungs is determined by the interaction of several factors, including lung shape, airway tree geometry, posture, and tissue deformation. Inter-species differences in lung structure-function and technical difficulty in obtaining high resolution imaging of the upright human lung means that it is not straightforward to experimentally determine the contribution of each of these factors to ventilation distribution. We present a mathematical model for predicting the topological distribution of inhaled air in the upright healthy human lung, based on anatomically structured model geometries and biophysical equations for model function. Gravitational deformation of the lung tissue is predicted using a continuum model. Airflow is simulated in anatomically based conducting airways coupled to geometrically simplified terminal acinar units with varying volume-dependent compliances. The predicted ventilation distribution is hence governed by local tissue density and elastic recoil pressure, airway resistance and acinar compliance. Results suggest that there is significant spatial variation in intrinsic tissue properties in the lungs. The model confirms experimental evidence that in the healthy lungs tissue compliance has a far greater effect than airway resistance on the spatial distribution of ventilation, and hence a realistic description of tissue deformation is essential in models of ventilation.


► We model the ventilation distribution in upright healthy human lungs.
► Anatomically accurate geometries are used to include spatial information.
► Tissue deformation simulations are coupled to the airflow simulations.
► Results compare well with whole lung measures and expected distribution patterns.
► Inclusion of realistic compliance distributions is essential in ventilation models.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 300, 7 May 2012, Pages 222–231
نویسندگان
, , ,