کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496795 1623912 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sonication-induced unfolding proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Sonication-induced unfolding proteins
چکیده انگلیسی

The methodology of predicting sonication-induced unfolding proteins (SUP) is presented in this study. The methodology bases on: (a) simulation of SUP by the excessive deviations of protein domains in regime of damped forced vibrations caused by critical level of involved acoustic energy, which is associated with temperature rise and acoustic pressure; (b) simulation of stochasticity of SUP by failures in jobs service in the queueing system with Markovian fluxes. The assessments of probability of SUP accounting the complex of parameters of pulsed ultrasound, biophysical properties of tissue and macromolecular crowding of insonated zone of tissue are considered.


► Assessments of probability of sonication-induced unfolding proteins are presented.
► The process is simulated by excessive deviations of protein domains in regime of damped forced vibrations.
► Stochasticity of process is simulated by failures in the queueing systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 298, 7 April 2012, Pages 77–81
نویسندگان
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