کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4496803 | 1623912 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: HIV transmissions by stage in dynamic sexual partnerships HIV transmissions by stage in dynamic sexual partnerships](/preview/png/4496803.png)
Most models assessing relative transmissions during different progressive stages of human immunodeficiency virus (HIV) infection assume that infections are transmitted through instantaneous sexual contacts. In reality, however, HIV will often be transmitted through repeated sex acts during partnerships that form and dissolve at varying rates. We sought to understand how dynamic sexual partnerships would influence transmissions during different progression stages of HIV infection: primary HIV infection (PHI) and chronic stage. Using a system of ordinary differential equations with a pair approximation technique, we constructed a model of HIV transmission in a homogeneous population in which sexual partnerships form and dissolve. We derived analytical expressions for useful epidemiological quantities such as basic reproduction number and also did simulation runs of the model. Partnership dynamics strongly influence transmissions during progressive stages of HIV infection. The fraction of transmissions during PHI has a U-shaped relationship with respect to the rate of partnership change, where the minimum and maximum occur given partnerships of about 100 days and fixed partnerships, respectively. Models that assume instantaneous contacts may overestimate transmissions during PHI for real, dynamic sexual partnerships with varying (non-zero) durations.
► We model HIV transmissions in a population where sexual partnerships form and dissolve over time.
► We use a combination of analytical and numerical methods.
► The role of primary HIV infection is lowest when sexual partnerships last around 100 days.
► Standard models of HIV transmission may not be adequate to study the role of primary HIV infection.
Journal: Journal of Theoretical Biology - Volume 298, 7 April 2012, Pages 147–153