کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497127 1318917 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A model for the dynamics of mammalian family X DNA polymerases
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A model for the dynamics of mammalian family X DNA polymerases
چکیده انگلیسی
Based on available structural studies, a model is presented for polymerization dynamics of mammalian family X DNA polymerases, including polymerases β, λ, μ, and terminal deoxynucleotidyl transferase (TdT). Using the model, distinct polymerization activities and processivities of the four polymerases acting on different forms of DNA substrate are analyzed and studied theoretically. A “gradient” of template dependence of polymerases β, λ, μ, and TdT is well explained. The much higher occurrence frequencies of the −1 frameshift DNA synthesis by pols λ and μ than that by pol β are well explained. The theoretical results on the polymerization processivities are also in agreement with the available experimental data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 277, Issue 1, 21 May 2011, Pages 111-122
نویسندگان
,