کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497400 1318932 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Genome analyses and modelling the relationships between coding density, recombination rate and chromosome length
چکیده انگلیسی

In the human genomes, recombination frequency between homologous chromosomes during meiosis is highly correlated with their physical length while it differs significantly when their coding density is considered. Furthermore, it has been observed that the recombination events are distributed unevenly along the chromosomes. We have found that many of such recombination properties can be predicted by computer simulations of population evolution based on the Monte Carlo methods. For example, these simulations have shown that the probability of acceptance of the recombination events by selection is higher at the ends of chromosomes and lower in their middle parts. The regions of high coding density are more prone to enter the strategy of haplotype complementation and to form clusters of genes, which are “recombination deserts”. The phenomenon of switching in-between the purifying selection and haplotype complementation has a phase transition character, and many relations between the effective population size, coding density, chromosome size and recombination frequency are those of the power law type.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 267, Issue 2, 21 November 2010, Pages 186–192
نویسندگان
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