کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497642 1318945 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phase organization of circadian oscillators in extended gate and oscillator models
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Phase organization of circadian oscillators in extended gate and oscillator models
چکیده انگلیسی

The suprachiasmatic nuclei (SCN) control daily oscillations in physiology and behavior. The gate–oscillator model captures functional heterogeneity in SCN and has been successful in reproducing many features of SCN. This paper investigates the mechanism of phase organization in the gate–oscillator model and finds that only stable fixed points of the phase transition function are essential to phase organization. This obvious finding forms the basis for understanding the complex phase distribution in the gate–oscillator scheme. Extending the model with a dead zone of the phase transition function and the propagation delay of the gate signal which may represent the spatial structure of SCN, the author discusses how some features of experimentally reported phase distribution, such as the existence of anti-phase neurons and fixed phase difference between neurons, could be understood in the framework of the gate–oscillator model. The extended model shows clearly the way in which the interplay between the single-cell property and the property of the network organization influence the phase distribution of SCN neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 264, Issue 2, 21 May 2010, Pages 367–376
نویسندگان
,