کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497724 1318948 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modeling growth and telomere dynamics in Saccharomyces cerevisiae
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Modeling growth and telomere dynamics in Saccharomyces cerevisiae
چکیده انگلیسی

A general branching process is proposed to model a population of cells of the yeast Saccharomyces cerevisiae following loss of telomerase. Previously published experimental data indicate that a population of telomerase-deficient cells regain exponential growth after a period of slowing due to critical telomere shortening. The explanation for this phenomenon is that some cells engage telomerase-independent pathways to maintain telomeres that allow them to become “survivors.” Our model takes into account random variation in individual cell cycle times, telomere length, finite replicative lifespan of mother cells, and survivorship. We identify and estimate crucial parameters such as the probability of an individual cell becoming a survivor, and compare our model predictions to experimental data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 263, Issue 3, 7 April 2010, Pages 353–359
نویسندگان
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