کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497774 1318949 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of adhesion on cellular invasion processes in cancer and development
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
The impact of adhesion on cellular invasion processes in cancer and development
چکیده انگلیسی

In this paper we consider a simple continuous model to describe cell invasion, incorporating the effects of both cell–cell adhesion and cell–matrix adhesion, along with cell growth and proteolysis by cells of the surrounding extracellular matrix (ECM). We demonstrate that the model is capable of supporting both noninvasive and invasive tumour growth according to the relative strength of cell–cell to cell–matrix adhesion. Specifically, for sufficiently strong cell–matrix adhesion and/or sufficiently weak cell–cell adhesion, degradation of the surrounding ECM accompanied by cell–matrix adhesion pulls the cells into the surrounding ECM. We investigate the criticality of matrix heterogeneity on shaping invasion, demonstrating that a highly heterogeneous ECM can result in a “fingering” of the invasive front, echoing observations in real-life invasion processes ranging from malignant tumour growth to neural crest migration during embryonic development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 264, Issue 3, 7 June 2010, Pages 1057–1067
نویسندگان
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