کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497999 1318960 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hazard function for cancer patients and cancer cell dynamics
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Hazard function for cancer patients and cancer cell dynamics
چکیده انگلیسی

The aim of the paper is to develop a procedure for an estimate of an analytical form of a hazard function for cancer patients. Although a deterministic approach based on cancer cell population dynamics yields the analytical expression, it depends on several parameters which should be estimated. On the other hand, a kernel estimate is an effective nonparametric method for estimating hazard functions. This method provides the pointwise estimate of the hazard function. Our procedure consists of two steps: in the first step we find the kernel estimate of the hazard function and in the second step the parameters in the deterministic model are obtained by the least squares method. A simulation study with different types of censorship is carried out and the developed procedure is applied to real data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 258, Issue 3, 7 June 2009, Pages 437–443
نویسندگان
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