کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4498798 1318999 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T cell development in the thymus: From periodic seeding to constant output
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
T cell development in the thymus: From periodic seeding to constant output
چکیده انگلیسی
T cell development occurs in the thymus throughout life. Recent experimental findings show that the seeding of the thymus by multi-potent stem cells from the bone marrow is periodic rather than continuous, as previously assumed. However it is well known that the output rate of cells from the thymus is relatively constant. A quantitative model is used to verify the current hypotheses regarding T cell development in the steady state mouse thymus. The results show that the thymus could be at a periodic steady state with out-of-phase thymocyte populations. Experiments to examine possible periodic fluctuations in the thymus are proposed and methods for further analysis are outlined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 249, Issue 2, 21 November 2007, Pages 384-394
نویسندگان
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