کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4499389 1319028 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Probing the effects of the well-mixed assumption on viral infection dynamics
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Probing the effects of the well-mixed assumption on viral infection dynamics
چکیده انگلیسی

Viral kinetics have been extensively studied in the past through the use of spatially well-mixed ordinary differential equations describing the time evolution of the diseased state. However, emerging spatial structures such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire can stop a forest fire from spreading. In a previous publication [Beauchemin, C., Samuel, J., Tuszynski, J., 2005. A simple cellular automaton model for influenza A viral infections. J. Theor. Biol. 232(2), 223–234], a simple two-dimensional cellular automaton model was introduced and shown to be accurate enough to model an uncomplicated infection with influenza A. Here, this model is used to investigate the effects of relaxing the well-mixed assumption. Particularly, the effects of the initial distribution of infected cells, the regeneration rule for dead epithelial cells, and the proliferation rule for immune cells are explored and shown to have an important impact on the development and outcome of the viral infection in our model.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 242, Issue 2, 21 September 2006, Pages 464–477
نویسندگان
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