کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499440 | 1319030 | 2007 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kinetic behaviour of proenzymes activation in the presence of different inhibitors for both activating and activated enzymes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Kinetic behaviour of proenzymes activation in the presence of different inhibitors for both activating and activated enzymes Kinetic behaviour of proenzymes activation in the presence of different inhibitors for both activating and activated enzymes](/preview/png/4499440.png)
چکیده انگلیسی
In the present paper, a kinetic analysis of a general model for proenzyme activation, where the activating enzyme and also the activated one are reversibly inhibited in two steps by two different inhibitors, has been performed. The cases in which both inhibitors are the same, or in which the inhibition is irreversible (only one or the two inhibition routes) are treated as particular cases of the general model. In addition, the kinetic behaviour of many other proenzyme activation systems involving inhibition, particular cases of the reaction scheme under study, can be obtained. The total number of particular cases for the general model under study is 370, so this approach offers to the scientific community working in limited proteolysis regulation for the first time a method based on general solutions which only needs to be specified to their concrete problem of zymogen activation. Finally, new adimensional parameters are introduced, allowing the knowledgement, in the case that any of the inhibition routes is irreversible, the relative weight of both activation and irreversible inhibition routes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 245, Issue 1, 7 March 2007, Pages 175-192
Journal: Journal of Theoretical Biology - Volume 245, Issue 1, 7 March 2007, Pages 175-192
نویسندگان
Edelmira Valero, Manuela GarcÃa-Moreno, Jesualdo Masiá, MarÃa-José GarcÃa-Meseguer, Ramón Varón,