کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499479 | 1319032 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Waning of maternal immunity and the impact of diseases: The example of myxomatosis in natural rabbit populations Waning of maternal immunity and the impact of diseases: The example of myxomatosis in natural rabbit populations](/preview/png/4499479.png)
Myxomatosis is a leporipoxvirus that infects the european rabbit, inducing a high mortality rate. Observations lead us to hypothesize that a rabbit carrying maternal antibodies (or having recovered) can be infected (or re-infected) upon being exposed (or re-exposed) to the virus. Infection will lead to mild disease, boosting host immune protection. Using a modelling approach we show that this phenomenon may lead to a difference of impact of myxomatosis according to its transmission rate. Young are exposed when they still carry maternal antibodies and develop a mild disease in high transmission populations. Our results show that the impact of myxomatosis is generally higher in epidemic situations compared to populations where the virus circulates all the year. As a consequence, waning of acquired immunity and the continuous supply of newborn along the year may reduce the impact of the disease.
Journal: Journal of Theoretical Biology - Volume 242, Issue 1, 7 September 2006, Pages 81–89