کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499484 | 1319032 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The recognition and prediction of Ï70 promoters in Escherichia coli K-12
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
Based on the conservation analysis of the 683 latest experimentally verified Ï70-promoter sequences of Escherichia coli K-12, it is found that the conservative hexamers segments in different sites play a key role of promoter regions, a novel position-correlation scoring matrix (PCSM) algorithm for predicting Ï70 promoter is presented. The predictive capacity of the algorithm is tested by 10-cross validation test. The results show that the overall prediction accuracies (sensitivity) and specificity are 91% and 81%, respectively. By selecting the 683 experimentally verified Ï70 promoters as training set and searching for the complete sequence in E. coli K-12 with 4639221Â bp. Results show that the 100% of the 683 experimentally verified Ï70 promoters have been identified and some possible promoters are predicted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 242, Issue 1, 7 September 2006, Pages 135-141
Journal: Journal of Theoretical Biology - Volume 242, Issue 1, 7 September 2006, Pages 135-141
نویسندگان
Qian-Zhong Li, Hao Lin,