کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499491 | 1319032 | 2006 | 17 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation](/preview/png/4499491.png)
The acute inflammatory response, triggered by a variety of biological or physical stresses on an organism, is a delicate system of checks and balances that, although aimed at promoting healing and restoring homeostasis, can result in undesired and occasionally lethal physiological responses. In this work, we derive a reduced conceptual model for the acute inflammatory response to infection, built up from consideration of direct interactions of fundamental effectors. We harness this model to explore the importance of dynamic anti-inflammation in promoting resolution of infection and homeostasis. Further, we offer a clinical correlation between model predictions and potential therapeutic interventions based on modulation of immunity by anti-inflammatory agents.
Journal: Journal of Theoretical Biology - Volume 242, Issue 1, 7 September 2006, Pages 220–236