کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4499632 1319039 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The standard genetic code enhances adaptive evolution of proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
The standard genetic code enhances adaptive evolution of proteins
چکیده انگلیسی

The standard genetic code, by which most organisms translate genetic material into protein metabolism, is non-randomly organized. The Error Minimization hypothesis interprets this non-randomness as an adaptation, proposing that natural selection produced a pattern of codon assignments that buffers genomes against the impact of mutations. Indeed, on the average any given point mutation has a lesser effect on the chemical properties of the utilized amino acid than expected by chance. Might it also, however, be the case that the non-random nature of the code effects the rate of adaptive evolution? To investigate this, here we develop population genetic simulations to test the rate of adaptive gene evolution under different genetic codes. We identify two independent properties of a genetic code that profoundly influence the speed of adaptive evolution. Noting that the standard genetic code exhibits both, we offer a new insight into the effects of the “error minimizing” code: such a code enhances the efficacy of adaptive sequence evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 239, Issue 1, 7 March 2006, Pages 63–70
نویسندگان
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