کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4520236 | 1625154 | 2016 | 7 صفحه PDF | دانلود رایگان |

• The biological activity of Callicarpa maingayi extract and fractions was evaluated.
• LC-DAD-ESI/MS was used to analyze the most active fractions.
• Twenty compounds were tentatively identified from active fractions.
• The compounds included 14 phenylpropanoids and 6 flavones.
Plants have an extensive diversity of natural phytochemicals that are used as a source of medicine. In this study the methanolic leaf extract of Callicarpa maingayi together with its increasing polarity soluble fractions hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (n-BuOH), and aqueous (Aq) fractions were examined on antioxidant, acetylcholinesterase (AChE), tyrosinase, and α-glucosidase inhibitory activities. Liquid chromatography-diode array detection-electrospray ionization-tandem mass spectrometry (LC-DAD-ESIMS/MS) was used to analyze the most bioactive fractions (EtOAc and n-BuOH). A total of 20 compounds were tentatively identified in these two active fractions. Forsythoside B, acteoside, isoacteoside, isocampneoside II, apigenin 7-O-rutinoside and kaempferol 3-sulfate-7-arabinopyranoside were identified by comparing with the reference standard. Other compounds including cistanoside F, apigenin 6-C-glucoside-8-C-glucoside, β-OH-forsythoside B, campneoside II, rhamnazin 3-O-rutinoside, campneoside I, eukovoside, acacetin diglucoronide, acacetin 7-O-glucuronide, β-OH-poliumoside, poliumoside as well as 3 isomers of 2′-acetylacteoside were tentatively identified based on their UV spectra and MS/MS data. All of the compounds were reported from this species for the first time. The results have indicated the chemical constituents of C. maingayi that contributed to the biological activity and thus, it may have potential application toward the development of nutraceutical and medicinal preparations.
Journal: South African Journal of Botany - Volume 104, May 2016, Pages 98–104