کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4530420 1324702 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Accumulation and disposition of hexabromocyclododecane (HBCD) in juvenile rainbow trout (Oncorhynchus mykiss)
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم آبزیان
پیش نمایش صفحه اول مقاله
Accumulation and disposition of hexabromocyclododecane (HBCD) in juvenile rainbow trout (Oncorhynchus mykiss)
چکیده انگلیسی

The brominated flame retardant hexabromocyclododecane (HBCD) has been reported in environmental samples worldwide. The three diastereomers, α-, β- and γ-HBCD, behave differently in aquatic food webs; likely depending on different factors influencing assimilation efficiency and metabolism. In the present study, two oral exposure experiments with rainbow trout were performed to assess the role of selective uptake on diastereomer-specific accumulation and disposition of HBCD to liver, brain and muscle. In both experiments, juvenile rainbow trout (Oncorhynchus mykiss) were administrated a technical HBCD-mixture in commercial feed (10 mg kg−1), followed by up to 21 days of food deprivation. Already 6 h after exposure, the HBCD accumulation was significant, and the concentrations peaked 4–8 days after the exposure. The relative change in HBCD pattern during the accumulation process (0–8 days), suggested that there was a diastereomer-selective uptake of α- and β-HBCD in the rainbow trout. During the initial 48 h, considerable amounts of all three diastereomers were distributed to liver, brain and muscle. A 70% reduction in ΣHBCD levels after 21 days, indicated elimination of HBCD from brain and liver, but no clear elimination from the muscle was observed. Differences in HBCD pattern between organs at the end of the experiment support a proposal of an organ-specific diastereomer accumulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 95, Issue 2, 8 November 2009, Pages 144–151
نویسندگان
, , , ,