کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4530667 1324721 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in gene expression due to chronic exposure to environmental pollutants
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم آبزیان
پیش نمایش صفحه اول مقاله
Changes in gene expression due to chronic exposure to environmental pollutants
چکیده انگلیسی

Populations of the teleost fish Fundulus heteroclitus inhabit and have adapted to highly polluted Superfund sites that are contaminated with persistent toxic chemicals. Populations inhabiting different Superfund sites provide independent contrasts for studying mechanisms of toxicity and resistance due to exposure to environmental pollutants. To identify both shared and unique responses to chronic pollutant exposure, liver, metabolic gene expression in F. heteroclitus populations from each of three Superfund sites (New Bedford Harbor, MA; Newark Bay, NJ; and Elizabeth River, VA) were compared to two flanking reference site populations (nine populations in total). In comparisons to their two clean reference sites, the three Superfund sites had 8–32% of genes with altered expression patterns. Between any two Superfund populations, up to nine genes (4%) show a conserved response, yet among all three populations, there was no gene which had a conserved, altered pattern of expression. Across all three Superfund sites in comparison to all six-reference populations, the most significant gene was fatty acid synthase. Fatty acid synthase is involved in the storage of excess energy as fat, and its lesser expression in the polluted populations suggests that the polluted populations may have limited energy stores. In contrast to previous studies of metabolic gene expression in F. heteroclitus, body weight was a significant covariate for many of the genes which could reflect accumulation and different body burdens of pollutants. Overall, the altered gene expression in these populations likely represents both induced and adaptive changes in gene expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 90, Issue 3, 21 November 2008, Pages 161–171
نویسندگان
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