A free boundary problem modeling the cell cycle and cell movement in multicellular tumor spheroids

This paper deals with a mathematical model describing the cell cycle dynamics and chemotactic driven cell movement in a multicellular tumor spheroid. Tumor cells consist of two types of cells: proliferating cells and quiescent cells, which have different chemotactic responses to an extracellular nutrient supply. The model is a free boundary problem for a nonlinear system of reaction–diffusion–advection equations, where the free boundary is the outer boundary of the spheroid. The free boundary condition is quite novel due to different velocity of two types of cells. The global existence and uniqueness of solutions to the model is proved. The proof is based on a fixed point argument, together with the Lp-theory for parabolic equations with the third boundary condition.