کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4633782 | 1340679 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparability of gene expression in human blood, immune and carcinoma cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The tissue-specific pattern of gene expression can provide important clues for clinical diagnosis and prognosis. Though high-density microarray technology offers the opportunity to examine patterns of mRNA expression on a genomic scale, accessible tissue is still a problem. We conducted secondary data analysis on transcriptional profiles of 79 human tissues using Affymetrix U133a microarrays. We found that expression among tissues belonging to the central nervous system shows distinctly similar patterns. The organ-free immune cells in peripheral blood are more comparable with leukemia/lymphoma at the transcriptome level, and differential co-expression patterns appear between tissue groups of organ-free immune and leukemia/lymphoma cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Mathematics and Computation - Volume 205, Issue 1, 1 November 2008, Pages 178–184
Journal: Applied Mathematics and Computation - Volume 205, Issue 1, 1 November 2008, Pages 178–184
نویسندگان
Xinan Yang, Xiao Sun, Jianming Xie, Zuhong Lu,