کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4752327 1416133 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration
ترجمه فارسی عنوان
چسب پروتئین جراحی برای درمان ریزش پوستی بدون شکر، کلاژن طبیعی التیام بخش
کلمات کلیدی
پروتئین چسبناک چسب جراحی کاربردی درمان زخم، سازمان کلاژن،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

Skin scarring after deep dermal injuries is a major clinical problem due to the current therapies limited to established scars with poor understanding of healing mechanisms. From investigation of aberrations within the extracellular matrix involved in pathophysiologic scarring, it was revealed that one of the main factors responsible for impaired healing is abnormal collagen reorganization. Here, inspired by the fundamental roles of decorin, a collagen-targeting proteoglycan, in collagen remodeling, we created a scar-preventive collagen-targeting glue consisting of a newly designed collagen-binding mussel adhesive protein and a specific glycosaminoglycan. The collagen-targeting glue specifically bound to type I collagen in a dose-dependent manner and regulated the rate and the degree of fibrillogenesis. In a rat skin excisional model, the collagen-targeting glue successfully accelerated initial wound regeneration as defined by effective reepithelialization, neovascularization, and rapid collagen synthesis. Moreover, the improved dermal collagen architecture was demonstrated by uniform size of collagen fibrils, their regular packing, and a restoration of healthy tissue component. Collectively, our natural healing-inspired collagen-targeting glue may be a promising therapeutic option for improving the healing rate with high-quality and effective scar inhibition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 134, July 2017, Pages 154-165
نویسندگان
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