کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4752468 | 1416150 | 2017 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy](/preview/png/4752468.png)
In this work, mitochondria-targeting gold nanostar (AuNS) and anticarcinogen DOX were co-encapsulated in hyaluronic acid (HA) protective shell for tumor-targeting synergistic photothermal/chemo-therapy. Cationic peptide R8 and mitochondria-targeting pro-apoptotic peptide TPP-KLA were co-decorated on AuNS to form AuNS-pep via Au-S bonds. Then, electronegative HA was further coated on the surface via electrostatic interaction for cancer cell targeting. During the coating process, DOX was also introduced via electrostatic interaction to obtain a versatile nanoplatform AuNS-pep/DOX@HA. It was found that the nanoplatform could be internalized into tumor cells via CD44 receptor-mediated recognition. Followed digestion by hyaluronidase (HAase), the therapeutic nanoplatform was able to release DOX for chemotherapy and mitochondria-targeting nanoheater AuNS-pep for near infrared (NIR) light triggered subcellular photothermal therapy (PTT). This tumor-targeting nanoplatform AuNS-pep/DOX@HA displayed prominent non-resistant or resistant tumor inhibition both in vitro and in vivo.
A versatile gold nanostar (AuNS)-based nanoplatform was constructed for tumor-targeting synergistic photothermal/chemo-therapy and it was found that this nanoplatform displayed prominent non-resistant or resistant tumor inhibition both in vitro and in vivo.405
Journal: Biomaterials - Volume 117, February 2017, Pages 92-104