کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4765109 1423854 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Data to genetic risk assessment on high-density cholesterol level associated polymorphisms in Hungarian general and Roma populations
ترجمه فارسی عنوان
داده ها برای ارزیابی خطر ژنتیکی در پلی مورفیسم های مرتبط با سطح کلسترول بالا در جمعیت های مجارستانی و رومی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی

Data obtained by genotyping single nucleotide polymorphisms (SNPs) related to high-density lipoprotein cholesterol (HDL-C) levels were utilized in Genetic Risk Score [unweighted (GRS) and weighted (wGRS)] computation on Hungarian general and Roma populations. The selection process of the SNPs as well as the results obtained are published in our research article (Piko et al., 2017) [1]. Linkage analyses were performed by study groups. Study populations were stratified by quintiles of weighted Genetic Risk Score. Multivariate linear regression analyses were performed using Genetic Risk Scores and HDL-C levels as dependent variables; and ethnicity, sex and age as independent variables. The study subjects were categorized into quintiles according their wGRS values. Associations of Genetic Risk Scores with plasma HDL-C levels (as a continuous variable) were observed in both populations. Finally, the two populations were merged and analyzed together by multivariate logistic regression where reduced plasma HDL-C level was the dependent variable; while ethnicity, age and sex were the independent ones.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Data in Brief - Volume 14, October 2017, Pages 354-359
نویسندگان
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