Elaborated DNA-binding specialities, in vitro medicated apoptosis and restrained malignancy of neotype water-soluble cationic porphyrin acylhydrazone Cu-complex

Cu-complexes based on tricationic porphyrin acylhydrazone ligands were synthesized. The physicochemical methods indicate that Cu-P4 with preferable DNA-binding constants due to its smaller molecular size. In addition, they exhibit superior cytotoxicity towards A549 and HepG2 carcinoma cells but weak for Hs 578Bst normal cells. Especially, the Cu-P4 displays better cytotoxicity in A549 than its analogues and induced cell death via chiefly late apoptosis and arrested S phase cells.334