Facile one-pot synthesis of hollow mesoporous fluorescent Gd2O3:Eu/calcium phosphate nanospheres for simultaneous dual-modal imaging and pH-responsive drug delivery

A feasible and effective one-step method was designed by using polyacrylic acid calcium as a template to prepare hollow mosoporous fluorescent Gd2O3:Eu/calcium phosphate nanospheres, which possess superior photoluminescence capacity, excellent T1-weighted MR imaging contrast, good biocompatibility and relatively high doxorubicin payload.503