کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4765806 | 1423890 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of fluorescent mitochondria probe based on 1,2-dihydropyrrolo[3,4-b]indolizine-3-one
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of fluorescent mitochondria probe based on 1,2-dihydropyrrolo[3,4-b]indolizine-3-one Development of fluorescent mitochondria probe based on 1,2-dihydropyrrolo[3,4-b]indolizine-3-one](/preview/png/4765806.png)
چکیده انگلیسی
Mitochondria are one of the most important organelles in our body. Recent studies showed morphology of polymorphous organelle mitochondria can be used as a relevant biological marker for certain diseases. In this study, we developed new fluorescent mitochondrial probe, 5, for monitoring mitochondrial morphology via rational probe design using 1,2-dihydropyrrolo[3,4-b]indolizine-3-one. To overcome the drawback of triphenylphosphonium incorporation, pyridinium group was introduced as a mitochondria targeting moiety. Additional incorporation of olefin moiety between pyridinium and indolizine core skeleton in 5 induced a bathochromic shift of both absorption and emission wavelength along with increased hydrophobicity. Finally, we found 5 selectively stains the mitochondria under the live-cell condition. This work indicated that a simple change of chemical structure in a certain organic fluorophore can cause a significant transition in staining pattern of bioprobes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 145, October 2017, Pages 461-468
Journal: Dyes and Pigments - Volume 145, October 2017, Pages 461-468
نویسندگان
June Sung, Youngjun Lee, Jeong-Hyeon Cha, Seung Bum Park, Eunha Kim,