کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932529 | 1433524 | 2017 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distinct brain metabolic patterns separately associated with cognition, motor function, and aging in Parkinson's disease dementia
ترجمه فارسی عنوان
الگوهای متمایز مغز مشخص شده به طور جداگانه همراه با شناخت، عملکرد حرکتی و پیری در بیماری پارکینسون دمانس
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کلمات کلیدی
FDGPiBFP-CITDopamine transporter - انتقال دهنده دوپامینBeta amyloid - بتا آمیلوئیدAlzheimer's disease - بیماری آلزایمرParkinson's disease dementia - بیماری پارکینسون دمانسMultivariate analysis - تحلیل چندمتغیرهDLB, Dementia with Lewy bodies - زوال عقل با اجسام لوییnetwork - شبکهGlucose metabolism - متابولیسم گلوکزPET - پت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We explored whether patients with Parkinson's disease dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent 3 separate positron emission tomography sessions with [18F]fluorodeoxyglucose (for glucose metabolism), fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (for dopamine transporter density) and Pittsburgh compound-B (for beta-amyloid load). We confirmed in PDD versus normal controls, overall hypometabolism in the posterior and prefrontal brain regions accompanied with hypermetabolism in subcortical structures and the cerebellar vermis. A multivariate network analysis then revealed 3 metabolic patterns that are separately associated with cognitive performance (p = 0.042), age (p = 0.042), and motor symptom severity (p = 0.039). The age-related pattern's association with aging was replicated in healthy controls (p = 0.047) and patients with Alzheimer's disease (p = 0.002). The cognition-related pattern's association with cognitive performance was observed, with a trend-level of correlation, in patients with dementia with Lewy bodies (p = 0.084) but not in patients with Alzheimer's disease (p = 0.974). We found no association with fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane and Pittsburgh compound-B positron emission tomography with patients' cognitive performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 60, December 2017, Pages 81-91
Journal: Neurobiology of Aging - Volume 60, December 2017, Pages 81-91
نویسندگان
Ji Hyun Ko, Audrey Katako, Maram Aljuaid, Andrew L. Goertzen, Andrew Borys, Douglas E. Hobson, Seok Min Kim, Chong Sik Lee, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,