کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932584 | 1433525 | 2017 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease
ترجمه فارسی عنوان
شامپانزه های سالم دارای علائم پاتولوژیک بیماری آلزایمر هستند
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کلمات کلیدی
بیماری آلزایمر، پروتئین آمیلوئید بتا، شامپانزه خلط نوروفیبریلیال، پرستار، تاو،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20, age 37-62 years) for evidence of Aβ and tau lesions in brain regions affected by AD in humans. Aβ was observed in plaques and blood vessels, and tau lesions were found in the form of pretangles, NFT, and tau-immunoreactive neuritic clusters. Aβ deposition was higher in vessels than in plaques and correlated with increases in tau lesions, suggesting that amyloid build-up in the brain's microvasculature precedes plaque formation in chimpanzees. Age was correlated to greater volumes of Aβ plaques and vessels. Tangle pathology was observed in individuals that exhibited plaques and moderate or severe cerebral amyloid angiopathy, a condition in which amyloid accumulates in the brain's vasculature. Amyloid and tau pathology in aged chimpanzees suggests these AD lesions are not specific to the human brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 59, November 2017, Pages 107-120
Journal: Neurobiology of Aging - Volume 59, November 2017, Pages 107-120
نویسندگان
Melissa K. Edler, Chet C. Sherwood, Richard S. Meindl, William D. Hopkins, John J. Ely, Joseph M. Erwin, Elliott J. Mufson, Patrick R. Hof, Mary Ann Raghanti,