کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932652 | 1433527 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Age-related plasticity of the axon initial segment of cortical pyramidal cells in marmoset monkeys
ترجمه فارسی عنوان
پلاستیسیته مربوط به سن مربوط به بخش اولیه آکسون سلول های هرم قارچی در میمون های مارمولک است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Structural plasticity of the axon initial segment (AIS), the site of action potential initiation, is observed as part of the normal early development of the cortex, as well as in association with injury and disease. Here, we show that structural AIS plasticity also occurs with normal aging in adult marmosets. Immunohistochemical techniques were used to reveal the extent of the AIS of layer 2/3A pyramidal cells in 8 neocortical areas. We found that the AIS length varied significantly between areas in young adult (2-3 years old) marmosets, with neurons in frontal area 14C having the longest AIS, and those in the primary visual cortex the shortest. Similar interareal differences were observed in aged (12-14 year old) monkeys, but the AIS was significantly shortened in many areas, relative to the corresponding length in young adults. Shortening of the AIS is likely to represent a compensatory response to changes in the excitation-inhibition balance, associated with the loss of GABAergic interneurons in the aged cortex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 57, September 2017, Pages 95-103
Journal: Neurobiology of Aging - Volume 57, September 2017, Pages 95-103
نویسندگان
Nafiseh Atapour, Marcello G.P. Rosa,