کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4932806 1433529 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants
چکیده انگلیسی
We examined possible age- and gender-related changes in binding of the selective antagonist N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) to metabotropic glutamate receptor type 1 in healthy human brains. Dynamic 11C-ITMM positron emission tomography scans (90 min) with serial arterial blood sampling were performed in 15 young and 24 older healthy adult volunteers. The total distribution volume (VT) of several brain regions was estimated with 2-tissue compartment model analysis. The VTs of the cerebellar cortex, parietal cortex, putamen, amygdala, and hippocampus in older adult participants were significantly higher than in young participants. The age-related VT increase was only observed in male participants. Our data suggest that an age-dependent increase in metabotropic glutamate receptor type 1 availability in several brain regions may exist predominantly in males.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 55, July 2017, Pages 72-77
نویسندگان
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