کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932904 | 1433536 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Age-related white-matter correlates of motor sequence learning and consolidation
ترجمه فارسی عنوان
ماده سفید مربوط به سن مربوط به یادگیری و تثبیت توالی حرکت موتور است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Older adults show impaired consolidation in motor sequence learning (MSL) tasks, failing to demonstrate the sleep-dependent performance gains usually seen in young individuals. To date, few studies have investigated the white-matter substrates of MSL in healthy aging, and none have addressed how fiber pathways differences may contribute to the age-related consolidation deficit. Accordingly, we used diffusion-weighted magnetic resonance imaging to explore how white-matter characteristics relate to performance using an explicit MSL task in young and older participants. Analysis revealed that initial learning scores were correlated to white-matter microstructure in the corticospinal tract and within the corpus callosum regardless of age. Furthermore, sleep-dependent consolidation scores, in young adults only, were related to white-matter tract organization in a frontal area where several major fiber bundles cross each other. These findings further our understanding of the neural correlates of MSL in healthy aging and provide the first evidence that age-related white-matter differences in tract configuration may underlie the age-related motor memory consolidation deficit.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 48, December 2016, Pages 13-22
Journal: Neurobiology of Aging - Volume 48, December 2016, Pages 13-22
نویسندگان
Catherine Vien, Arnaud Boré, Ovidiu Lungu, Habib Benali, Julie Carrier, Stuart Fogel, Julien Doyon,