کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
493551 721930 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Probabilistic models for drug dissolution. Part 1. Review of Monte Carlo and stochastic cellular automata approaches
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
Probabilistic models for drug dissolution. Part 1. Review of Monte Carlo and stochastic cellular automata approaches
چکیده انگلیسی

Throughout the last decades, Monte Carlo (MC) techniques have been used in simulating various complex systems. In this paper, we investigate how MC-based methods are used in the field of Drug Delivery, indicating what aspects of the complex problems of drug dissolution and design can benefit from this particular approach. After introducing the area of modelling drug dissolution, with its different features and needs, we report and examine the existing Direct MC and Stochastic Cellular Automata modelling efforts used to simulate dissolution of pharmaceutical compacts or related phenomena. In Part 2, we enlarge on a description of our work on Direct MC, for the particular case of simulating a binary system consisting of poorly soluble drug dispersed in a matrix of highly-soluble acid excipient.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Simulation Modelling Practice and Theory - Volume 14, Issue 7, October 2006, Pages 843–856
نویسندگان
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