کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4952978 692658 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Geometric and mechanical properties evaluation of scaffolds for bone tissue applications designing by a reaction-diffusion models and manufactured with a material jetting system
ترجمه فارسی عنوان
ارزیابی هندسی و خواص مکانیکی داربست ها برای استفاده از بافت های استخوان طراحی شده توسط مدل های واکنش انتشار و ساخته شده با یک سیستم جت مواد
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر گرافیک کامپیوتری و طراحی به کمک کامپیوتر
چکیده انگلیسی


- We model scaffolds structures for bone tissue engineering using a reaction-diffusion system.
- Geometrical properties such as channel width can be adjusted using this methodology.
- Mechanical and geometrical features of parts made using a material jetting system are described.

Scaffolds are essential in bone tissue engineering, as they provide support to cells and growth factors necessary to regenerate tissue. In addition, they meet the mechanical function of the bone while it regenerates. Currently, the multiple methods for designing and manufacturing scaffolds are based on regular structures from a unit cell that repeats in a given domain. However, these methods do not resemble the actual structure of the trabecular bone which may work against osseous tissue regeneration. To explore the design of porous structures with similar mechanical properties to native bone, a geometric generation scheme from a reaction-diffusion model and its manufacturing via a material jetting system is proposed. This article presents the methodology used, the geometric characteristics and the modulus of elasticity of the scaffolds designed and manufactured. The method proposed shows its potential to generate structures that allow to control the basic scaffold properties for bone tissue engineering such as the width of the channels and porosity. The mechanical properties of our scaffolds are similar to trabecular tissue present in vertebrae and tibia bones. Tests on the manufactured scaffolds show that it is necessary to consider the orientation of the object relative to the printing system because the channel geometry, mechanical properties and roughness are heavily influenced by the position of the surface analyzed with respect to the printing axis. A possible line for future work may be the establishment of a set of guidelines to consider the effects of manufacturing processes in designing stages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Computational Design and Engineering - Volume 3, Issue 4, October 2016, Pages 385-397
نویسندگان
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