کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
495674 862833 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improving the design of sequences for DNA computing: A multiobjective evolutionary approach
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Improving the design of sequences for DNA computing: A multiobjective evolutionary approach
چکیده انگلیسی


• We propose a multiobjective evolutionary algorithm for DNA sequence design.
• The algorithm uses a matrix-based chromosome as encoding strategy.
• The algorithm uses specific recombination operators.
• We show that our approach may improve the performance for this problem compared to previous methods.

Designing oligonucleotide strands that selectively hybridize to reduce undesired reactions is a critical step for successful DNA computing. To accomplish this, DNA molecules must be restricted to a wide window of thermodynamical and logical conditions, which in turn facilitate and control the algorithmic processes implemented by chemical reactions. In this paper, we propose a multiobjective evolutionary algorithm for DNA sequence design that, unlike preceding evolutionary approaches, uses a matrix-based chromosome as encoding strategy. Computational results show that a matrix-based GA along with its specific genetic operators may improve the performance for DNA sequence optimization compared to previous methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Soft Computing - Volume 13, Issue 12, December 2013, Pages 4594–4607
نویسندگان
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