کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
495674 | 862833 | 2013 | 14 صفحه PDF | دانلود رایگان |

• We propose a multiobjective evolutionary algorithm for DNA sequence design.
• The algorithm uses a matrix-based chromosome as encoding strategy.
• The algorithm uses specific recombination operators.
• We show that our approach may improve the performance for this problem compared to previous methods.
Designing oligonucleotide strands that selectively hybridize to reduce undesired reactions is a critical step for successful DNA computing. To accomplish this, DNA molecules must be restricted to a wide window of thermodynamical and logical conditions, which in turn facilitate and control the algorithmic processes implemented by chemical reactions. In this paper, we propose a multiobjective evolutionary algorithm for DNA sequence design that, unlike preceding evolutionary approaches, uses a matrix-based chromosome as encoding strategy. Computational results show that a matrix-based GA along with its specific genetic operators may improve the performance for DNA sequence optimization compared to previous methods.
Journal: Applied Soft Computing - Volume 13, Issue 12, December 2013, Pages 4594–4607