Influence of gray level and space discretization on brain tumor heterogeneity measures obtained from magnetic resonance images

Tumor texture studies based on images with different characteristics (e.g. multi-center studies) should first fix the dynamic range to be considered. For studies involving images of different resolutions either (i) only robust measures should be used (in our study CM entropy, RLM HGRE and/or RLM LGRE) or (ii) images should be resampled to match those of the lowest resolution before computing the textural features.