کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4966914 1449304 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generating disease-pertinent treatment vocabularies from MEDLINE citations
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Generating disease-pertinent treatment vocabularies from MEDLINE citations
چکیده انگلیسی


- Biomedical literature is a useful source for disease-specific medical knowledge.
- A method is proposed for automated retrieving disease-specific treatments.
- Our approach achieved a precision of 0.80 at top 100 treatment concepts.
- Our approach outperformed two baseline approaches.
- No significant difference on the precision of top 100 among four ranks.

ObjectiveHealthcare communities have identified a significant need for disease-specific information. Disease-specific ontologies are useful in assisting the retrieval of disease-relevant information from various sources. However, building these ontologies is labor intensive. Our goal is to develop a system for an automated generation of disease-pertinent concepts from a popular knowledge resource for the building of disease-specific ontologies.MethodsA pipeline system was developed with an initial focus of generating disease-specific treatment vocabularies. It was comprised of the components of disease-specific citation retrieval, predication extraction, treatment predication extraction, treatment concept extraction, and relevance ranking. A semantic schema was developed to support the extraction of treatment predications and concepts. Four ranking approaches (i.e., occurrence, interest, degree centrality, and weighted degree centrality) were proposed to measure the relevance of treatment concepts to the disease of interest. We measured the performance of four ranks in terms of the mean precision at the top 100 concepts with five diseases, as well as the precision-recall curves against two reference vocabularies. The performance of the system was also compared to two baseline approaches.ResultsThe pipeline system achieved a mean precision of 0.80 for the top 100 concepts with the ranking by interest. There were no significant different among the four ranks (p = 0.53). However, the pipeline-based system had significantly better performance than the two baselines.ConclusionsThe pipeline system can be useful for an automated generation of disease-relevant treatment concepts from the biomedical literature.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomedical Informatics - Volume 65, January 2017, Pages 46-57
نویسندگان
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