A comparison of microfiltration and inertia-based microfluidics for large scale suspension separation

Considering their effectiveness, inertia-based microfluidic separation is regarded an interesting alternative to microfiltration; therefore, this paper focusses on the use of inertial forces in suspension separation. This resulted in the selection of three concepts, which were: (1) fluid skimming, which is a combination of microfiltration and controlled particle migration behaviour, (2) spiral inertial microchannel separation, in which particles migrate fast towards an equilibrium position, and (3) sparse deterministic ratchets, which use geometric interactions to induce particle migration. In a concluding section, the application of controlled migration behaviour in relation to scalability of inertia-based microfluidic separation techniques and the effect of suspension properties on separation are discussed in detail.