کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
499405 863043 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A computational framework for derivative-free optimization of cardiovascular geometries
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
A computational framework for derivative-free optimization of cardiovascular geometries
چکیده انگلیسی

Predictive simulation and optimization-based design tools have great potential to improve the design of surgeries and interventions used in cardiovascular medicine. The present work builds upon recent advances in blood flow simulation capabilities to develop tools for optimization. A framework for coupling optimal shape design to time-accurate three-dimensional blood flow simulations in idealized cardiovascular geometries is presented. The optimization method employed is a tailored version of the surrogate management framework, a method that was developed previously for expensive functions with little or no gradient information. In this method, we employ a derivative-free approach using surrogates for increased efficiency together with mesh adaptive direct search to guarantee convergence to a local minimum. The optimization procedure has been fully automated to include the generation and parameterization of three-dimensional solid geometries, mesh generation, finite element flow computation, post processing and optimization. This methodology is demonstrated on three model problems that are representative of typical cardiovascular geometries: a stenosis, a vessel bifurcation modeled on Murray’s law, and an end-to-side anastomosis. These problems are used to illustrate the importance of the choice of cost function and the performance of the optimization algorithm. This framework for treatment optimization will be applicable to a wide range of cardiovascular surgical or catheter-based interventions in future work.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods in Applied Mechanics and Engineering - Volume 197, Issues 21–24, 1 April 2008, Pages 1890–1905
نویسندگان
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