کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5008673 | 1462037 | 2018 | 9 صفحه PDF | دانلود رایگان |
- A molecularly imprinted polymer coated on CdTe quantum dots (MIP-QDs) was developed for the determination of amoxicillin.
- MIP-QDs showed a high sensitivity and selectivity for amoxicillin over other antibiotics.
- The developed method was applied to determine amoxicillin levels in food samples with a good recovery (85-102%).
A facile method for coating a molecularly imprinted polymer onto CdTe quantum dots (MIP-QDs) was successfully formulated and for the first time used as a highly selective and sensitive photoluminescence probe for the determination of trace amoxicillin. The MIP-QDs were prepared using a sol-gel process with 3-aminopropylethoxysilane as a functional monomer, tetraethoxysilane as a cross-linker and amoxicillin as a template molecule. After removal of the template molecule from the polymer layer, MIP-QDs containing cavities specific to amoxicillin were obtained. The hydrogen bonding between the amino group of 3-aminopropylethoxysilane and functional groups of amoxicillin and the specific size and shape of the cavity provided good selectivity. The photoluminescence intensity of MIP-QDs was more strongly quenched by amoxicillin compared to a non-imprinted polymer (NIP-QDs) with an imprinting factor of 43.6. Under optimum conditions, the photoluminescence intensity of MIP-QDs was decreased in response to increase amoxicillin concentration with good linearity in the range of 0.20-50.0 μg Lâ1. The limit of detection and the limit of quantitation were 0.14 μg Lâ1 and 0.46 μg Lâ1, respectively. The developed method showed good repeatability and reproducibility with the relative standard deviation being less than 6%. This developed method was successfully applied for the determination of amoxicillin in egg, milk and honey samples with a satisfactory recovery of 85-102% being achieved.
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Journal: Sensors and Actuators B: Chemical - Volume 254, January 2018, Pages 255-263