کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5008847 | 1462040 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A self-assembled peptide nanotube-chitosan composite as a novel platform for electrochemical cytosensing
ترجمه فارسی عنوان
کامپوزیت نانو لوله کیتوزان پپتید خودآموز به عنوان یک پلت فرم جدید برای سیتوزن الکتروشیمیایی
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کلمات کلیدی
مونتاژ پپتید، کیتوزان، کامپوزیت، سیتوزن الکتروشیمیایی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A novel peptide nanotube and chitosan composite (PNT-CS) is prepared by self-assembly of dipeptide monomers in a CS aqueous solution. A scanning electron microscopy image showed that the composite had a three-dimensional (3D) network structure. Contact angle analysis indicated good hydrophilicity of the PNT-CS. X-ray diffraction patterns and FT-IR spectra revealed that the basical crystallinity properties and assembled manner of the PNTs in the composite could be maintained. Electrochemical characterization demonstrated that the PNT-CS had good conductivity and excellent stability during the electrochemical measurements. The composite combined the advantages of the two constituent materials and was further employed as an electrochemical cytosensor for the detection of cancer cells (K562). The linear range from 5 Ã 103 to 5 Ã 107 cells mLâ1 with a detection limit of 630 cells mLâ1 was obtained at the PNT-CS-modified electrodes using the electrochemical impedance method. These results are comparable with the previously reported cytosensors based on conventional nanomaterials. Nevertheless, the present method is very simple and suitable for down-up fabrication. The combination of the electrochemical properties, easy preparation, and excellent biocompatibility makes the PNT-CS a promising platform for next generation cytosensors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 251, November 2017, Pages 86-92
Journal: Sensors and Actuators B: Chemical - Volume 251, November 2017, Pages 86-92
نویسندگان
Meiling Lian, Xu Chen, Xuejiao Liu, Zongchun Yi, Wensheng Yang,